Reply to Ng and Tan

Reply to Ng and Tan.

TO THE EDITOR—We thank Drs Ng and Tan for their interesting data from Singapore and for their feedback on our review [1, 2]. The high rates of accuracy and acceptability reported from Singapore are encouraging. We agree that pricing and willingness to pay are essential considerations that are likely to vary substantially from one setting to the next. We also agree that it will be unfortunate if...

Reply to Tan et al.: Differences between real and simulated proteins in multiple sequence alignments.

Tan et al. (1) comment on our earlier paper regarding the accuracy of multiple sequence alignments (MSAs) using different guide tree topologies (2). We stress that the scope of our result was confined to alignments of very large numbers of protein sequences with known structures, where accuracy was measured against structure-based alignments. We point out that this result could not be translate...

The Authors’ Reply

Tan 16_8

To clarify the potential involvement of plasmin(ogen) cascade proteins in the cell dissociation and subsequent invasion of pancreatic cancer cells, Western blot analysis, immunocytochemistry, immunohistochemistry, and in vitro invasion assay were performed in the cell lines or tissue of pancreatic cancer. The strong expression of plasmin(ogen), urokinase type plasminogen activator (uPA) and uPA...

The Authors’ Reply